Combobox datasource has been assigned with
cmbCombobox.DataSource = myCollection
where myCollection has type MyCollection: List
How can I clear items in combobox?
When you data bind a control, it will synchronize with that collection. In order to clear the items in your ComboBox set it's DataSource to null.
cmbComboBox.DataSource = null;
If your combobox is not databound (no DataSource) then you can do
cmbComboBox.Items.Clear();