Do I have to do the configuration for nservicebus on mvc4 that would be handled by the EndpointConfig.cs?

In the examples, most of the config is done by the dev by changing AsA_Server to AsA_Client.

public class EndpointConfig : IConfigureThisEndpoint, AsA_Client { }

However, I can't seem to do that with an ASP.NET MVC4 app.
Do I have to manually configure everything in a web environment?

Yes, here are links to the documentation:

• http://support.nservicebus.com/customer/portal/articles/894008-using-nservicebus-with-asp-net-mvc
• http://support.nservicebus.com/customer/portal/articles/894123-injecting-the-bus-into-asp-net-mvc-controller

You can also have a look at our sample projects for examples on how to do it, see https://github.com/NServiceBus/NServiceBus/tree/master/Samples/AsyncPagesMVC3

There is also a sample that uses MVC4 but that is against NServiceBus v4 which has not been released yet, see https://github.com/Particular/NServiceBus/tree/develop/Samples/VideoStore.Msmq/VideoStore.ECommerce