If the throughput is increase how will be changed the response and request time? If I have the data(request/min)?
JMeter's definition of throughput can be seen here: https://jmeter.apache.org/usermanual/glossary.html
Basically its a measure of how many requests that JMeter were able to send to your test site/application in one second. Or in another word the number of requests that your test site/application was able to receive from JMeter in one second. An increase in the throughput will mean your site/application was able to receive more requests per second while a decrease will mean a reduction in the number of request it handled per second.
The relationship between throughput with response/request time totally depends as ysth stated. I typically use this number to see the load of the server but run the test several times (30x min) and take the average.