I am getting the following error while trying to configure FileStream in SQL server 2012.
There was an unknown error applying the filestream settings. check the parameters are valid. (0x80041008)
I am configuring it using SQL server configuration manager.
Where as I am able to setup it for SQL server 2008 R2.
I had this same problem just yesterday.
In my case it was because I had a 64-bit Windows and a 32-Bit SQL Server.
You do not see the exact error, but if you try to do it with T-SQL, then the proper error comes up in SQL, telling you something about "WOW64" not supporting filestream.
I just uninstalled and installed the right bit version of SQL, and all worked 100% again.