Didn't find class "android.support.multidex.MultiDexApplication" on path: DexPathList

I'm trying the new MultiDex Support on my app and so far I've managed to compile my app correctly, but when running it, I get the following exception:

java.lang.RuntimeException: Unable to instantiate application android.support.multidex.MultiDexApplication: java.lang.ClassNotFoundException: Didn't find class "android.support.multidex.MultiDexApplication" on path: DexPathList[[zip file "/data/app/me.myapp.main-2.apk"],nativeLibraryDirectories=[/data/app-lib/me..main-2, /vendor/lib, /system/lib]]
    at android.app.LoadedApk.makeApplication(LoadedApk.java:507)
    at android.app.ActivityThread.handleBindApplication(ActivityThread.java:4382)
    at android.app.ActivityThread.access$1500(ActivityThread.java:139)
    at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1270)
    at android.os.Handler.dispatchMessage(Handler.java:102)
    at android.os.Looper.loop(Looper.java:136)
    at android.app.ActivityThread.main(ActivityThread.java:5086)
    at java.lang.reflect.Method.invokeNative(Native Method)
    at java.lang.reflect.Method.invoke(Method.java:515)
    at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:785)
    at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:601)
    at dalvik.system.NativeStart.main(Native Method)
Caused by: java.lang.ClassNotFoundException: Didn't find class "android.support.multidex.MultiDexApplication" on path: DexPathList[[zip file "/data/app/me.myapp.main-2.apk"],nativeLibraryDirectories=[/data/app-lib/me.myapp.main-2, /vendor/lib, /system/lib]]
    at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
    at java.lang.ClassLoader.loadClass(ClassLoader.java:497)
    at java.lang.ClassLoader.loadClass(ClassLoader.java:457)
    at android.app.Instrumentation.newApplication(Instrumentation.java:998)
    at android.app.LoadedApk.makeApplication(LoadedApk.java:502)

This is my gradle file:

apply plugin: 'com.android.application'

android {
    compileSdkVersion 21
    buildToolsVersion "21.1.0"

    defaultConfig {
        minSdkVersion 16
        targetSdkVersion 21
        multiDexEnabled true
    }
    buildTypes {
        release {
            minifyEnabled true
            proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.txt'
        }
        debug {
            minifyEnabled false
            proguardFiles getDefaultProguardFile('proguard-android.txt'), 'proguard-rules.txt'
        }
    }
    packagingOptions {
        exclude 'META-INF/LICENSE.txt'
        exclude 'META-INF/NOTICE.txt'
    }
}

repositories {
    mavenCentral()
    mavenLocal()
}


dependencies {
    compile 'com.android.support:multidex:1.0.0'
    compile fileTree(include: ['*.jar'], dir: 'libs')
    compile 'com.android.support:support-v4:21.0.0'
    compile 'com.android.support:support-v13:21.0.0'
    compile 'com.android.support:appcompat-v7:21.0.0'
}

And my AndroidManifest.xml:

<application
android:name="android.support.multidex.MultiDexApplication">

I don't understand what the problem is. I think I'm doing everything according to the documentation. Is there something else i am missing? I made sure I had the latest support library and repo installed from the SDK manager.

My configuration:

buildscript {
    repositories {
        mavenCentral()
    }
    dependencies {
        classpath 'com.android.tools.build:gradle:0.14.+' // 0.14.1, 2014-11-6
    }
}

dependencies {
    compile 'com.android.support:multidex:1.0.0'
}

android {
    compileSdkVersion = 21
    buildToolsVersion = "21.1.0"

    defaultConfig {
        minSdkVersion 14
        targetSdkVersion 21
        multiDexEnabled true
    }
}

Unfortunately, I have the same problem. But I found a strange situation:

build/intermediates/dex/debug:

-rw-rw-r--  1 andrew andrew  2221176 Nov  6 20:18 classes2.dex
-rw-rw-r--  1 andrew andrew  8357596 Nov  6 20:18 classes.dex

unzip apk, build/outputs/apk:

-rw-rw-r-- 1 andrew andrew 8357596 Nov  6 20:18 classes2.dex
-rw-rw-r-- 1 andrew andrew 2221176 Nov  6 20:18 classes.dex

In apk, the main classes of classes.dex should be bigger than classes2.dex, but its not. I do also dex2jar & unzip jar to check classes, the application class is not there in classes.dex, its in classes2.dex contrarily.

However, I should have fixed it. Here is my patched android gradle plugin you can try:

buildscript {
    repositories {
        mavenCentral()
        maven { url 'https://github.com/yongjhih/android-gradle-plugin.m2/raw/master/' }
    }
    dependencies {
        classpath 'com.infstory.tools.build:gradle:0.14.+'
    }
}

The patch is in: https://github.com/yongjhih/android-gradle-plugin/commit/9c2212e3b1b4c6e1f7b47f2086aba1903a6258bf or https://android-review.googlesource.com/#/c/113331/

issue: https://code.google.com/p/android/issues/detail?id=78761

The official patch is https://android-review.googlesource.com/#/c/113201/ that already been merged, I think it might be fixed in next version.

Already been fixed 0.14.2 (2014/11/10). (from http://tools.android.com/tech-docs/new-build-system)

Release notes:

0.14.2 (2014/11/10)

Fix potential multi-dex issue where the dex files could be renamed during packaging, leading to the wrong main dex file being used.
Fix versionNameSuffix support
Fix BuildType.initWith to copy shrinkResources flag
setup default proguard rule file if none are provided (SDK/tools/proguard/proguard-android.txt)
BuildType.pseudoLocalesEnabled flag to include fake locales in apk.