Is it possible to debug Perl that contains XS sections to see the program flow?

I have a project written in Perl with XS components written in C++. I am debugging with command like

perl -d perl_file.pl

How I can use the debugger to jump from Perl into those C++ files?

You could use GNU Project Debugger.

gdb /usr/bin/perl
    r perl_file.pl

See perlhacktips:

• Using gdb to look at specific parts of a program
• Using gdb to look at what the parser/lexer are doing

Also see:

• Get a stack trace from your running perl
• App::Stacktrace