I'm not finding a way to do this in the chrome.* API or even the experimental. It doesn't run through wscript so
ActiveXObject("Shell.Application")
isn't allowed.
I fear that my only option is to build a dll with NPAPI but I wanted to see if there was a simpler way.
If you want to do anything Natively, you need to use NPAPI. That allows you to run code outside the sandbox for your extensions.