Is there a feasible way to trigger CSS keyframe animation using JS?

Naturally, we can create a CSS animation using keyframes, and control it from there.

However, ideally, I would like to trigger this animation from a button click - so the button click would be an event...

@keyframes fade-in {
    0% {opacity: 0;}
    100% {opacity: 1;}
}

Now, on click, I want to trigger this animation; as opposed to from within the CSS animation property.

see here jsfiddle

if you want your animation to work every time you press the button use this code :

$('button').click(function() {
    $(".fademe").addClass('animated');
    setTimeout(function() {
      $(".fademe").removeClass('animated');
    }, 1500);
});

where 1500 is the animation-duration in this case, 1.5s

$('button').click(function() {
  $(".fademe").addClass('animated');
  setTimeout(function() {
    $(".fademe").removeClass('animated');
  }, 1500);
});

.fademe {
  width: 100px;
  height: 100px;
  background: red;
}

.fademe.animated {
  animation: fade-in 1.5s ease;
}


@keyframes fade-in {
  0% {
    opacity: 0;
  }

  100% {
    opacity: 1;
  }
}

<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.3.1/jquery.min.js"></script>
<div class="fademe">

</div>

<button>CLICK ME</button>

EXPLANATION :

1. on click on the button add class animated ( or any other class ) to the element you want to apply the animation to , .fademe
2. make a setTimeout(function() to delay the removeClass for the duration of the animation 1.5s or 1500ms
3. write in CSS the declaration of the animation , @keyframes, and add it to the element with the class added by the JQ .fademe.animated