In google cloud functions it is easy to shell out and even run native linux binaries using child_process.execSync(command), which is how I was able to get gcf.cr to run native crystal code in google cloud functions.
Playing around with Cloudflare Workers at a glance this doesn't seem to be possible as it seems I can't even do require('child_process');.
Does Cloudflare Workers not allow shelling out? If so then it's usefulness greatly diminishes for me unfortunately.
Cloudflare Workers runs on top of V8 isolates, not a process-level container. This has several advantages, like near-instant cold starts, but means it's not possible to run arbitrary binaries.
What type of application are you hoping to run? Is it something which can be compiled to WebAssembly?