How to upsert pandas DataFrame to PostgreSQL table?

I've scraped some data from web sources and stored it all in a pandas DataFrame. Now, in order harness the powerful db tools afforded by SQLAlchemy, I want to convert said DataFrame into a Table() object and eventually upsert all data into a PostgreSQL table. If this is practical, what is a workable method of going about accomplishing this task?

Update: You can save yourself some typing by using this method.

If you are using PostgreSQL 9.5 or later you can perform the UPSERT using a temporary table and an INSERT ... ON CONFLICT statement:

import sqlalchemy as sa

# …

with engine.begin() as conn:
    # step 0.0 - create test environment
    conn.exec_driver_sql("DROP TABLE IF EXISTS main_table")
    conn.exec_driver_sql(
        "CREATE TABLE main_table (id int primary key, txt varchar(50))"
    )
    conn.exec_driver_sql(
        "INSERT INTO main_table (id, txt) VALUES (1, 'row 1 old text')"
    )
    # step 0.1 - create DataFrame to UPSERT
    df = pd.DataFrame(
        [(2, "new row 2 text"), (1, "row 1 new text")], columns=["id", "txt"]
    )
    
    # step 1 - create temporary table and upload DataFrame
    conn.exec_driver_sql(
        "CREATE TEMPORARY TABLE temp_table AS SELECT * FROM main_table WHERE false"
    )
    df.to_sql("temp_table", conn, index=False, if_exists="append")

    # step 2 - merge temp_table into main_table
    conn.exec_driver_sql(
        """\
        INSERT INTO main_table (id, txt) 
        SELECT id, txt FROM temp_table
        ON CONFLICT (id) DO
            UPDATE SET txt = EXCLUDED.txt
        """
    )

    # step 3 - confirm results
    result = conn.exec_driver_sql("SELECT * FROM main_table ORDER BY id").all()
    print(result)  # [(1, 'row 1 new text'), (2, 'new row 2 text')]