I upgraded to matplotlib 3.3.3 and I can no longer change the color of a single tick when plotting.
Using matplotlib 3.2.1 the following code
import matplotlib.pyplot as plt
plt.ylim(0,3)
ax = plt.gca()
y_label_positions = [0,1,2,3]
y_label_strings = ["0", "1", "2", "3"]
ax.set_yticks(y_label_positions)
ax.set_yticklabels(y_label_strings)
ax.yaxis.get_ticklines()[2].set_markeredgewidth(5)
ax.yaxis.get_ticklines()[2].set_color("red")
plt.savefig("foo.pdf")
works fine and changes the tick's size and color,
but the same code with Matplotlib 3.3.3 only changes the size of the tick, not its color.