Fatal Python error: init_fs_encoding: failed to get the Python codec of the filesystem encoding, when trying to start uwsgi

I am trying to start my uwsgi server in my virtual environment, but after I added plugin python3 option I get this error every time:

!!! Python Home is not a directory: /home/env3/educ !!!
Set PythonHome to /home/env3/educ
Python path configuration:
  PYTHONHOME = '/home/env3/educ'
  PYTHONPATH = (not set)
  program name = '/home/env3/educ/bin/python'
  isolated = 0
  environment = 1
  user site = 1
  import site = 1
  sys._base_executable = '/home/env3/educ/bin/python'
  sys.base_prefix = '/home/env3/educ'
  sys.base_exec_prefix = '/home/env3/educ'
  sys.executable = '/home/env3/educ/bin/python'
  sys.prefix = '/home/env3/educ'
  sys.exec_prefix = '/home/env3/educ'
  sys.path = [
    '/home/env3/educ/lib/python38.zip',
    '/home/env3/educ/lib/python3.8',
    '/home/env3/educ/lib/python3.8/lib-dynload',
  ]
Fatal Python error: init_fs_encoding: failed to get the Python codec of the filesystem encoding
Python runtime state: core initialized
ModuleNotFoundError: No module named 'encodings'

Current thread 0x00007efe89db8780 (most recent call first):
<no Python frame>

Also I tried to create new virtual environment using python3 -m venv env and moved project files to it, but still the same error. Here is my uwsgi.ini file:

[uwsgi]

base = /home/env3/educ
projectname = educ

plugins = python3
master = true
virtualenv = /home/env3/%(projectname)
pythonpath = %(base)
env = DJANGO_SETTINGS_MODULE=%(projectname).settings.pro
module = %(projectname).wsgi:application
socket = /tmp/%(projectname).sock
chmod-socket = 666

I use Python 3.8.5

I am trying to use Django + uWSGI + nginx + Postgresql.

Solution

I see your PYTHONHOME is set to PYTHONHOME = '/home/env3/educ'. Try to check if it is really there.

The solution for me was to remove the PYTHONHOME environment variable. For you, it can be just that, or setting that variable to another value. This worked on Windows, and would work on Linux for sure. If someone tries this on Linux, please post a comment here !

A CPython developer confirmed the solution here. :

This is not a Python bug, this is a symptom of setting PYTHONHOME and/or PYTHONPATH when they’re not needed. In nearly all cases you don’t need to set either of them;

In the case of PYTHONHOME it’s almost always a mistake to set.