Fade/transition tailwind class to something else over certain amount of time?

Is there a way to set bg-red-300 and fade/transition it to bg-transparent or different bg class over 2 seconds or do I need javascript for this? I want an element to highlight and then return to normal after 2 secs. Thank you!

You may create your own animation with config file

module.exports = {
  mode: 'jit',
  theme: {
    extend: {
      
      // that is animation class
      animation: {
        fade: 'fadeOut 5s ease-in-out',
      },

      // that is actual animation
      keyframes: theme => ({
        fadeOut: {
          '0%': { backgroundColor: theme('colors.red.300') },
          '100%': { backgroundColor: theme('colors.transparent') },
        },
      }),
    },
  },
  variants: {},
  plugins: [],
}

Use it like

<div class="w-40 h-40 animate-fade"></div>

Demo

P.S. However you may probably need some Javascript to trigger animate-fade classlist toggling or something as animation will proceed no matter does block is in viewport or not.