I'm using multiMiR package to for miRNA target retrieval. Till yesterday this package was running fine and now it is showing following error:
library(multiMiR)
Error: package or namespace load failed for ‘multiMiR’:
.onLoad failed in loadNamespace() for 'multiMiR', details:
call: function (type, msg, asError = TRUE)
error: Failed to connect to multimir.org port 80: Connection refused
I tried to reinstall multiMiR package and restart rstudio. but still, it is showing the same error. I don't understand how to solve this connection problem.
The below link I checked but I don't understand if that's the problem with my query here. https://askubuntu.com/questions/676434/port-80-connection-refused
Any help will be appreciated. please find below session info:
> sessionInfo()
R version 4.1.0 (2021-05-18)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.1252 LC_CTYPE=English_United States.1252
[3] LC_MONETARY=English_United States.1252 LC_NUMERIC=C
[5] LC_TIME=English_United States.1252
attached base packages:
[1] stats graphics grDevices utils datasets methods base
loaded via a namespace (and not attached):
[1] Rcpp_1.0.7 lattice_0.20-44 corpcor_1.6.9 png_0.1-7
[5] Biostrings_2.60.1 snow_0.4-3 assertthat_0.2.1 digest_0.6.27
[9] foreach_1.5.1 utf8_1.2.1 RSpectra_0.16-0 R6_2.5.0
[13] GenomeInfoDb_1.28.1 stats4_4.1.0 RSQLite_2.2.7 httr_1.4.2
[17] ggplot2_3.3.5 pillar_1.6.1 zlibbioc_1.38.0 rlang_0.4.11
[21] rstudioapi_0.13 blob_1.2.1 S4Vectors_0.30.0 Matrix_1.3-4
[25] DT_0.18 reticulate_1.20 Rtsne_0.15 htmlwidgets_1.5.3
[29] RCurl_1.98-1.3 bit_4.0.4 munsell_0.5.0 umap_0.2.7.0
[33] compiler_4.1.0 pkgconfig_2.0.3 askpass_1.1 BiocGenerics_0.38.0
[37] htmltools_0.5.1.1 doSNOW_1.0.19 openssl_1.4.4 tidyselect_1.1.1
[41] KEGGREST_1.32.0 GenomeInfoDbData_1.2.6 tibble_3.1.2 matrixcalc_1.0-4
[45] IRanges_2.26.0 codetools_0.2-18 XML_3.99-0.6 fansi_0.5.0
[49] crayon_1.4.1 dplyr_1.0.7 bitops_1.0-7 grid_4.1.0
[53] jsonlite_1.7.2 gtable_0.3.0 lifecycle_1.0.0 DBI_1.1.1
[57] magrittr_2.0.1 scales_1.1.1 cachem_1.0.5 XVector_0.32.0
[61] doParallel_1.0.16 ellipsis_0.3.2 generics_0.1.0 vctrs_0.3.8
[65] iterators_1.0.13 tools_4.1.0 bit64_4.0.5 Biobase_2.52.0
[69] glue_1.4.2 purrr_0.3.4 M3C_1.14.0 parallel_4.1.0
[73] fastmap_1.1.0 AnnotationDbi_1.54.1 colorspace_2.0-2 BiocManager_1.30.16
[77] cluster_2.1.2 memoise_2.0.0
This seems to be a (hopefully) temporary issue. The error does not seem to be on your side - at the time of writing the site multimir.org is currently down, which is why you are getting an error.
As the package depends on connection to external database, I encourage you to raise an issue on their repository.
EDIT July 20th 2021: The site is now up.