This just seems odd to me, most other things are lower case.
Is there some historical reason?
It's a macro. Macros have historically had all caps in C. Unfortunately recent trends appear to have broken that fact.
Small history lesson: Also, FILE was an io buffer abstraction in UNIX v7 libc stdio. A FILE doesn't necessarily represent a physical file, just something that can do block IO. Source:
http://www.bsdlover.cn/study/UnixTree/V7/usr/include/stdio.h.html
"file" was already defined by the kernel as well:
http://www.bsdlover.cn/study/UnixTree/V7/usr/include/sys/file.h.html
As someone else said here it's probably a typedef now, but I don't think C had typedefs back in '79 as it only just had structs. Then again I wasn't born then so... :)