I know there are a lot of anwsers to this question, but so far nothing has worked for me.
On MacOS Big Sur (m1 mac), when running my script (with or without sudo) it says: Access denied (insufficient permissions)
I am using the ev3-dc library. Any help would be amazing
The problem was that pyusb was unable to access the ev3 mindstorms. So I made a pull request to change it to to hidapi and it works great.