Snakemake in cluster different ways

When running snakemake on a cluster, and if we don't have specific requirements for some rules about number of cores/memory, then what is the difference between :

• Using the classic way, i.e. calling snakemake on the login node, telling it that executor is slurm and that we want X jobs with X cores each, optionally with a profile config file (1 job = 1 rule)
• Using snakemake like a normal tool, and call it with srun inside a sbatch script without telling it that this is a slurm environment (1 job = whole pipeline)

Example of the second option:

#!/bin/bash
#SBATCH --job-name=test_sbatch_snakemake
#SBATCH --nodes=1
#SBATCH --ntasks=1
#SBATCH --cpus-per-task=64

srun snakemake --cores 64                       \
               --latency-wait 30                \
               --nolock                         \
               --configfile configs/S_with_N.yaml

I have a pipeline where I don't have any specific capacity requirement for my rules (I just want the maximum of them running in parallel), and I think the second option is easier to implement.

With the second way, your whole workflow will have to wait in the queue before individual rule instances can start. With the first way the resource demand will be spread across the jobs that snakemake will submit, so each rule has a chance to start earlier than what you would have to wait in the second way.

(I use a third way: I sbatch a snakemake command that uses slurm as executor. In our cluster, it is considered bad practice to run the main snakemake on the submit/login node. This main snakemake doesn't wait too much in the queue, because it doesn't have to claim a lot of resources.)