Looking for a good replacement for Psyco (Python->C compiler)

We really like Psyco to speed things up, but it also has some drawbacks:

• it consumes too much memory
• it can also slow some code down
• compiling your code can take too much time
• it doesn't support 64-bit systems

What would be good alternatives (Django support required)?

You could try using PyPy, which is an implementation of Python in Python. It is a replacement for the standard CPython implementation and boasts large speed increases.

From its website:

Speed: thanks to its Just-in-Time compiler, Python programs often run faster on PyPy.

Memory usage: large, memory-hungry Python programs might end up taking less space than they do in CPython.

Compatibility: PyPy is highly compatible with existing python code. It supports ctypes and can run popular python libraries like twisted and django.