I'm looking to get up to speed on Python:
Is it worth working locally via the ActivePython interface, then progressing to a website that supports one of the standard frameworks (Django or Pylons) OR utilize the Google Apps environment?
I want to stay as interactive as possible - making feedback/learning easier.
Go with the Python interpreter. Take one of the tutorials that many people on SO recommend and you're on your way. Once you're comfortable with the language, have a look at a framework like Django, but not sooner.