I think the question speaks for itself..
My concern is, we would be modifying some PHP files here and there. Will the accelerator(s) know that it needs to recompile modified files (i assume they would, common sense)?
However, i didnt find any documentation on this matter.
That said, would it help (speed up) installing PHP accelerators on development environment (say localhost)?
Unless you are debugging your cacher, caching should be turned off for development.