Best practices to follow/read large mailing-lists?

You're probably a lot to be subscribers to various mailing list, some more updated than others.

• What are your best practices to follow all information going by these lists?
• What are the best clients you've used to managed that?

I'm sure I'm not the only one trying to get the best signal out of this noisy way of communication :)

I like gmail because of the way it groups messages by conversation so I can just page down through a thread.